U.S., March 28 -- ClinicalTrials.gov registry received information related to the study (NCT07496216) titled 'Closed Versus Open Lateral Internal Sphincterotomy for Chronic Anal Fissure' on March 22.
Brief Summary: This randomized controlled trial will compare closed versus open lateral internal sphincterotomy (LIS) under spinal anesthesia in patients with chronic anal fissure. The study will evaluate wound healing rates, postoperative pain, return to work, anal incontinence, and recurrence. A total of 160 patients will be randomized equally to either closed LIS or open LIS. The primary outcome will be complete wound healing at 6 weeks. Secondary outcomes include pain at 24 hours measured by Visual Analog Scale (VAS), return to work (days)...