U.S., April 30 -- ClinicalTrials.gov registry received information related to the study (NCT07556172) titled 'Clinical Study of Esketamine in Patients With Sepsis Undergoing Invasive Mechanical Ventilation' on June 11, 2025.
Brief Summary: Sepsis is a syndrome of acute organ dysfunction resulting from dysregulated host responses to infection, often leading to severe complications such as acute lung injury and ARDS. ICU patients on mechanical ventilation face multiple noxious stimuli and require effective analgesic and sedative treatments to improve prognosis. The limitations of existing analgesic and sedative drugs are as follows:Opioids (such as remifentanil) have strong analgesic effects but can easily cause adverse reactions such as res...