Clinical Trial: Characterization of Adaptive Immune Responses to Oropouche Virus (OROV) Infection

U.S., Nov. 7 -- ClinicalTrials.gov registry received information related to the study (NCT07921641) titled 'Characterization of Adaptive Immune Responses to Oropouche Virus (OROV) Infection' on Nov. 02.

Brief Summary: Oropouche virus (OROV), a re-emerging South American arbovirus causing dengue-like fever and occasional neurological complications, is expanding its circulation towards more densely populated areas in French Guiana, as evidenced by recent cases near Cayenne in 2026. While animal models indicate that B cell-mediated humoral immunity is critical for viral control, the human antibody response to OROV remains poorly characterized. Despite WHO-led international research efforts, there is currently no vaccine, antiviral treatment, ...