Clinical Trial: Assessing the Impact of Unnecessary Antibiotic Treatment on the Development of Appropriate Adaptive Immune Responses in Malnourished Bangladeshi Infants

U.S., May 30 -- ClinicalTrials.gov registry received information related to the study (NCT07615842) titled 'Assessing the Impact of Unnecessary Antibiotic Treatment on the Development of Appropriate Adaptive Immune Responses in Malnourished Bangladeshi Infants' on May 22.

Brief Summary: We are examining the role of circulating T follicular helper (Tfh) cells in the induction of the antibody responses. We hypothesize that Tfh cell activation is impaired in Bangladeshi children and that this activation failure is associated with a history of antibiotic use. The results of our preliminary studies suggest that antibiotic treatment could have a detrimental effect on the development of an appropriate adaptive immune response against Cryptosporid...