U.S., March 19 -- ClinicalTrials.gov registry received information related to the study (NCT07479550) titled 'Anesthesia-Masked Psilocybin Therapy for Major Depression' on March 08.
Brief Summary: Major depressive disorder (MDD) affects millions of Americans and remains difficult to treat. Psilocybin, a psychedelic compound, has shown promise for reducing depression symptoms, but a key challenge in psychedelic research is that participants can usually tell whether they received the active drug - making it hard to conduct fully blinded studies.
This study tests a new approach: administering psilocybin while participants are under general anesthesia, so that the noticeable psychological effects of psilocybin are masked. This allows both par...