Clinical Trial: Adding Preoperative Radiotherapy Based on Early Treatment Response in Breast Cancer

U.S., Oct. 24 -- ClinicalTrials.gov registry received information related to the study (NCT07892508) titled 'Adding Preoperative Radiotherapy Based on Early Treatment Response in Breast Cancer' on Oct. 11.

Brief Summary: RAPID-NeoBC is a prospective, multicentre, response-adapted study with a randomized component for adults with operable, nonmetastatic invasive breast cancer receiving guideline-recommended neoadjuvant systemic therapy. After two treatment cycles, participants with stable disease on blinded central imaging review are randomized 1:1 to continue standard care alone or to receive standard care plus response-adapted preoperative radiotherapy. The primary outcome is centrally reviewed pathological complete response in the breast...