U.S., Aug. 14 -- ClinicalTrials.gov registry received information related to the study (NCT07763548) titled 'A Novel Two-Step Dosing Induction Strategy (The Propofol Challenge Test) to Minimize Propofol Injection Pain' on Aug. 10.
Brief Summary: Propofol is the most widely used intravenous hypnotic agent for the induction of general anesthesia owing to its rapid onset and short duration of action. Despite its favorable pharmacokinetics and widespread use, a notable drawback persists: the incidence of pain on injection. Statistics on the matter are widely variable, but some estimates indicate that the incidence of pain with propofol injection is around 70%1.
To date, no studies have systematically evaluated whether dividing the induction d...