U.S., Sept. 30 -- ClinicalTrials.gov registry received information related to the study (NCT07848061) titled 'A Master Regulator of Lipid-Associated Macrophage Function in Cancer' on Sept. 23.
Brief Summary: Cancer progression is shaped not only by genetic alterations but also by systemic and local metabolic changes that influence the tumor microenvironment (TME). In particular, dysregulated lipid metabolism and micronutrient availability can modulate immune cell function and favor the accumulation of immunosuppressive myeloid populations associated with tumor growth, immune evasion, and poor clinical outcome.
Among tumor-infiltrating myeloid cells, macrophages show high metabolic plasticity and adapt their phenotype in response to enviro...