U.S., March 14 -- ClinicalTrials.gov registry received information related to the study (NCT07470424) titled 'A Clinical Study of Piperaquine, Pyronaridine, and Artesunate Administered in Combination in Healthy Adults' on March 09.
Brief Summary: This is an open-label pharmacokinetic study in 24 healthy Thai participants. Participants will be admitted in the inpatient ward and each participant will attend a total of 4 visits, including one screening visit and three hospital admissions. Participants will be randomized into one of six groups.
Each group will receive 3 drug regimens consisting of (1) piperaquine, (2) pyronaridine plus artesunate, or (3) piperaquine, pyronaridine, and artesunate, administered once per day for three consecutiv...