Mumbai, Feb. 27 -- Key Indian stock indices traded with major losses in mid-afternoon trade as investors remained cautious amid continued selling by foreign institutional investors (FII) and weak global cues. Geopolitical tensions escalated after Pakistan and Afghanistan declared open conflict, while US-Iran talks concluded without a resolution, adding to market uncertainty. The Nifty dropped below the 25,300 level.

Pharma shares declined after advancing in the past five consecutive trading session.

At 14:28 IST, the barometer index, the S&P BSE Sensex declined 577.35 points or 0.72% to 81,671.26. The Nifty 50 index tumbled 196.40 points or 0.78% to 25,298.90.

In the broader market, the BSE 150 MidCap Index declined 0.62% and the BSE 2...