Singapore, March 9 -- US-based Sartorius is addressing the increasing demand for faster and more efficient cell line development (CLD) by launching a new genetically engineered CHO host cell line that improves productivity and efficiency. The team leveraged proteomic profiling and targeted genome editing to generate the rational-design host cell line, which multiplies productivity by up to three-fold.

Sartorius tested the new CHO host cell line across multiple CLD campaigns from DNA to lead clone expressing a range of different therapeutic proteins. At five-liter bioreactor scale, the new host demonstrated up to a two-fold increase in expression titers, and up to a three-fold increase in productivity when directly compared against lead c...