Singapore, May 11 -- Researchers at A*STAR Genome Institute of Singapore (A*STAR GIS) have developed a breakthrough functional genomics technology that enables scientists to study how genes function within intact living tissue, offering an unprecedented view into how diseased cells interact with surrounding healthy cells.

The new technology, called Spatial Perturb-Seq, overcomes a major limitation of conventional genomic methods, which typically require tissues to be broken down into individual cells. While effective for analysing isolated cells, these approaches lose critical information about how cells communicate and influence one another within their natural environment.

By preserving tissue architecture and cellular positioning, Sp...