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Singapore Clinical Trial: A randomized, double-blind, placebo-controlled study to evaluate the effect of dupilumab on airway inflammation through assessments of mucus plugging and other lung imaging parameters in patients with chronic obstructive pulmonary disease

Singapore, May 31 -- The Health Sciences Authority received information related to the study titled 'A randomized, double-blind, placebo-controlled study to evaluate the effect of dupilumab on airway ... Read More


Singapore Clinical Trial: CA088-1007: A Phase 3, Randomized, Open-Label, Multicenter Study to Compare the Efficacy and Safety of Arlocabtagene Autoleucel (BMS-986393), a GPRC5D-directed CAR-T Cell Therapy, Versus Standard Regimens in Adult Participants with Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)

Singapore, May 31 -- The Health Sciences Authority received information related to the study titled 'CA088-1007: A Phase 3, Randomized, Open-Label, Multicenter Study to Compare the Efficacy and Safety... Read More


Singapore Clinical Trial: A Multinational, Multicenter, Prospective, Randomized, Controlled, Open-Label, Phase 3 Study of Lutetium-177 (177Lu) Rosopatamab Tetraxetan in Combination with Standard of Care Versus Standard of Care Alone in Patients with Prostate-Specific Membrane Antigen (PSMA) Positive Metastatic Castration-Resistant Prostate Cancer (mCRPC) after Androgen Receptor Pathway Inhibitor (ARPI) Treatment

Singapore, May 31 -- The Health Sciences Authority received information related to the study titled 'A Multinational, Multicenter, Prospective, Randomized, Controlled, Open-Label, Phase 3 Study of Lut... Read More


Singapore Clinical Trial: CO45042: A Phase III, Randomized, Open-Label Study Evaluating the Efficacy and Safety of Divarasib Plus Pembrolizumab Versus Pembrolizumab And Pemetrexed And Carboplatin or Cisplatin in Patients with Previously Untreated, KRAS G12C-Mutated, Advanced Or Metastatic Non-Squamous Non-Small Cell Lung Cancer

Singapore, May 31 -- The Health Sciences Authority received information related to the study titled 'CO45042: A Phase III, Randomized, Open-Label Study Evaluating the Efficacy and Safety of Divarasib ... Read More


Singapore Clinical Trial: A Phase III, Open-label, Randomised Study of Datopotamab Deruxtecan (Dato-DXd) With or Without Durvalumab Compared with Investigator’s Choice of Chemotherapy (Paclitaxel, Nab-paclitaxel or Gemcitabine + Carboplatin) in Combination With Pembrolizumab in Patients with PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05)

Singapore, May 31 -- The Health Sciences Authority received information related to the study titled 'A Phase III, Open-label, Randomised Study of Datopotamab Deruxtecan (Dato-DXd) With or Without Durv... Read More


International Clinical Trial: Research on the effects and mechanisms of KLF5-GPNMB on postoperative delirium by modulating microglial polarization in elderly patients

Geneva, June 8 -- International Clinical Trials Registry received information related to the study (ChiCTR2600125753) titled 'Research on the effects and mechanisms of KLF5-GPNMB on postoperative deli... Read More


International Clinical Trial: A Randomized, Controlled, Open-Label, Single-Center Clinical Trial of Aiplolitowrelizumab plus Lenvatinib as Adjuvant Therapy in Patients with High-Risk Recurrent Hepatocellular Carcinoma after TACE Followed by Thermal Ablation

Geneva, June 8 -- International Clinical Trials Registry received information related to the study (ChiCTR2600125756) titled 'A Randomized, Controlled, Open-Label, Single-Center Clinical Trial of Aipl... Read More


International Clinical Trial: Low-Dose Cyclosporine Combined with Eltrombopag in Patients with Primary Immune Thrombocytopenia Refractory or Dependent to First-Line Glucocorticoid Treatment

Geneva, June 8 -- International Clinical Trials Registry received information related to the study (ChiCTR2600125760) titled 'Low-Dose Cyclosporine Combined with Eltrombopag in Patients with Primary I... Read More


International Clinical Trial: Study on the role of MDH2 lactylation in tumor microcirculation abnormalities

Geneva, June 8 -- International Clinical Trials Registry received information related to the study (ChiCTR2600125755) titled 'Study on the role of MDH2 lactylation in tumor microcirculation abnormalit... Read More


International Clinical Trial: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase II Clinical Study to Evaluate the Efficacy and Safety of Different Doses of Injectable Coenzyme I (NAD+) in the Treatment of Ovarian Function Decline

Geneva, June 8 -- International Clinical Trials Registry received information related to the study (ChiCTR2600125759) titled 'A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase II Clini... Read More