ALEXANDRIA, Va., Feb. 3 -- United States Patent no. 12,539,317, issued on Feb. 3, was assigned to ZBiotics Co. (San Francisco).
"Gene expression system for probiotic microorganisms" was invented by Zachary D. Abbott (Daly City, Calif.).
According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are recombinant microorganisms that express a subject polypeptide. Microorganisms can comprise an expression construct comprising a flagellin promoter operatively linked with a heterologous nucleotide sequence encoding the subject polypeptide. The flagellin promoter sequence can comprise a genetic modification that reduces CsrA inhibition of translation. Microorganisms also can comprise a genetic modification that r...