US Patent Issued to Yale University on Feb. 24 for "Poly(amine-co-ester) polymers with modified end groups and enhanced pulmonary delivery" (Connecticut Inventors)

ALEXANDRIA, Va., Feb. 24 -- United States Patent no. 12,558,429, issued on Feb. 24, was assigned to Yale University (New Haven, Conn.).

"Poly(amine-co-ester) polymers with modified end groups and enhanced pulmonary delivery" was invented by W. Mark Saltzman (New Haven, Conn.), Yuhang Jiang (New Haven, Conn.), Molly Grun (New Haven, Conn.) and Alexandra Suberi (New Haven, Conn.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Poly(amine-co-ester) polymers, methods of forming active agent-load polyplexes and particles therefrom, and methods of using them for delivery of nucleic acid agents with optimal uptake have been developed. Examples demonstrate critical molecular weights in combination with exposed carboxy...