ALEXANDRIA, Va., April 7 -- United States Patent no. 12,594,325, issued on April 7, was assigned to Yale University (New Haven, Conn.).
"Interleukin-18 variants and methods of use" was invented by Aaron Ring (New Haven, Conn.), Ting Zhou (New Haven, Conn.) and Suzanne Fischer (New Haven, Conn.).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides compositions and methods comprising an activator of interleukin-18 (IL-18) activity for use in therapeutic and non-therapeutic applications. The activator provides IL-18 signaling activity even in the presence of an inhibitory molecule 5 such as IL-18 binding protein (IL-18BP)."
The patent was filed on Nov. 8, 2024, under Application No. 18/...