ALEXANDRIA, Va., Aug. 12 -- United States Patent no. 12,703,748, issued on Aug. 11, was assigned to Xencor Inc. (Pasadena, Calif.).
"Anti-CD28 compositions" was invented by John R. Desjarlais (Pasadena, Calif.), Gregory Moore (Azusa, Calif.), Michael Hedvat (Encino, Calif.), Juan Diaz (Anaheim Hills, Calif.) and Veronica Gusti Zeng (Duarte, Calif.).
According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are novel anti-CD28 x anti-B7H3 (also referred to as "AlphaCD28 x AlphaB7H3") heterodimeric bispecific antibodies and methods of using such antibodies for the treatment of cancers. Subject AlphaCD28 x AlphaB7H3 antibodies are capable of agonistically binding to CD28 costimulatory molecules on T cells an...