US Patent Issued to Wisconsin Alumni Research Foundation on June 23 for "Site-selective deuteration of amino acids through dual protein catalysis" (Wisconsin Inventors)

ALEXANDRIA, Va., July 15 -- United States Patent no. 12,662,688, issued on June 23, was assigned to Wisconsin Alumni Research Foundation (Madison, Wis.).

"Site-selective deuteration of amino acids through dual protein catalysis" was invented by Andrew Buller (Madison, Wis.) and Tyler Doyon (Eau Claire, Wis.).

According to the abstract* released by the U.S. Patent & Trademark Office: "A method for site-selective deuteration of amino acids using a protein system having an aminotransferase (e.g., DsaD) and/or a small partner protein (e.g., DsaE). A non-deuterated amino acid is contacted with deuterium and an aminotransferase or a combination of an aminotransferase and a partner protein, to yield a CAlpha-deuterated or a CAlpha- and CBeta-deu...