US Patent Issued to Washington University on March 17 for "Dominant negative SARM1 molecules comprising a substitution at position 189, 190, 193, 194, 570 and/or 685 of SARM1" (Missouri Inventors)

ALEXANDRIA, Va., March 17 -- United States Patent no. 12,576,130, issued on March 17, was assigned to Washington University (St. Louis).

"Dominant negative SARM1 molecules comprising a substitution at position 189, 190, 193, 194, 570 and/or 685 of SARM1" was invented by Aaron DiAntonio (St. Louis), Jeffrey D. Milbrandt (St. Louis), Daniel Summers (St. Louis), Stefanie Geisler (St. Louis) and Xianrong Mao (St. Louis).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides compositions useful as inhibitors of SARM1 activity, pharmaceutical compositions thereof, and methods of using the same. The present invention provides dominant negative SARM1 molecules useful for treating a neurodegener...