US Patent Issued to Washington University on June 2 for "Split intein mediated protein polymerization for microbial production of materials" (Missouri Inventors)

ALEXANDRIA, Va., June 2 -- United States Patent no. 12,643,928, issued on June 2, was assigned to Washington University (St. Louis).

"Split intein mediated protein polymerization for microbial production of materials" was invented by Fuzhong Zhang (St. Louis), Christopher H. Bowen (St. Louis) and Bin Dai (St. Louis).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure is directed to systems and methods for synthesizing a spidroin. In some embodiments, the methods comprise synthesizing a monomer in vivo in a heterologous host, the monomer comprising an N-terminus IntC domain and a C-terminus IntN domain, and post-translationally polymerizing the synthesized monomer via in vitro split-intein me...