US Patent Issued to Vertex Pharmaceuticals on June 16 for "Compositions and methods for editing beta-globin for treatment of hemaglobinopathies" (Massachusetts Inventors)

ALEXANDRIA, Va., June 16 -- United States Patent no. 12,653,860, issued on June 16, was assigned to Vertex Pharmaceuticals Inc. (Boston).

"Compositions and methods for editing beta-globin for treatment of hemaglobinopathies" was invented by Sanjay D'Souza (Cambridge, Mass.), Jason West (Lexington, Mass.), Brenda K. Eustace (Brookline, Mass.) and Sudipta Mahajan (Boston).

According to the abstract* released by the U.S. Patent & Trademark Office: "The disclosure features methods of correcting a mutation in the human beta-globin (HBB) gene in a cell or population of cells. The disclosure also features methods of increasing repair of a DNA double stranded break (DSB) in an HBB gene by the homology-directed repair (HDR) pathway. The disclosure...