ALEXANDRIA, Va., March 24 -- United States Patent no. 12,584,109, issued on March 24, was assigned to Upside Foods Inc. (Berkeley, Calif.).

"Engineering cell lines capable of proliferation in growth factor free media formulations" was invented by Sukhdeep Singh Dhadwar (El Cerrito, Calif.) and Rachel Michele Schumaker (Emeryville, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are methods of engineering a cell line for reduced dependence on exogenous growth factor(s). In some embodiments, the method includes introducing into a cell one or more of: a polynucleotide comprising a coding sequence of a growth factor ligand; a polynucleotide comprising a coding sequence of a growth factor re...