US Patent Issued to UNIVERSITY OF VIRGINIA PATENT FOUNDATION on Nov. 3 for "ATP-independent bioluminescent reporter variants to improve in vivo imaging" (Virginia, Washington Inventors)

ALEXANDRIA, Va., Nov. 3 -- United States Patent no. 12,781,203, issued on Nov. 3, was assigned to UNIVERSITY OF VIRGINIA PATENT FOUNDATION (Charlottesville, Va.).

"ATP-independent bioluminescent reporter variants to improve in vivo imaging" was invented by Huiwang Ai (Crozet, Va.), Hsien-Wei Yeh (Seattle) and Ying Xiong (Charlottesville, Va.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are chemically modified luciferase substrates for spectrally shifted emission and enhanced water solubility. Provided herein are engineered luciferases. Moreover, provided herein are new ATP-independent bioluminescent reporters which have improved biochemical and photophysical properties and are expected to h...