US Patent Issued to University of South Florida on March 31 for "Methods of downregulating CCL20 genes for treatment of traumatic brain injuries" (Florida Inventors)

ALEXANDRIA, Va., March 31 -- United States Patent no. 12,589,133, issued on March 31, was assigned to University of South Florida (Tampa, Fla.).

"Methods of downregulating CCL20 genes for treatment of traumatic brain injuries" was invented by Subhra Mohapatra (Lutz, Fla.), Shyam S. Mohapatra (Lutz, Fla.), Karthick Mayilsamy (Tampa, Fla.) and Eleni Markoutsa (Tampa, Fla.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Compositions and methods for treating traumatic brain injury (TBI) are presented. Novel dendriplexes are formed from poly(amidoamine) (PAMAM) dendrimers complexed with shRNA encoding DNA plasmids encapsulating shRNA encoding chemokine ligand 20 (CCL20) gene, chemokine receptor 6 (CCR6) gene, or a...