US Patent Issued to UNIVERSITY OF SOUTH CAROLINA on Feb. 24 for "Optimization of type IV BRAF inhibitors for the treatment of melanoma" (South Carolina Inventors)

ALEXANDRIA, Va., Feb. 24 -- United States Patent no. 12,559,733, issued on Feb. 24, was assigned to UNIVERSITY OF SOUTH CAROLINA (Columbia, S.C.).

"Optimization of type IV BRAF inhibitors for the treatment of melanoma" was invented by Campbell McInnes (Irmo, S.C.) and Chad Beneker (Columbia, S.C.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Inhibitory peptides for modifying RAF kinase protein dimerization are described. The peptides display a binding affinity for the dimer interface of a B-Raf, allowing for modification of RAF kinase dimerization, and inhibition of tumor growth. An embodiment of the disclosure is a peptide generated by modifying SEQ ID NO: 1, which corresponds to amino acids 503-521 of B-R...