US Patent Issued to UNIVERSITY OF PUERTO RICO on Oct. 6 for "1,5-disubstituted 1,2,3-triazoles are inhibitors of RAC/CDC42 GTPases" (Puerto Rico Inventors)

ALEXANDRIA, Va., Oct. 6 -- United States Patent no. 12,753,183, issued on Oct. 6, was assigned to UNIVERSITY OF PUERTO RICO (San Juan, Puerto Rico).

"1,5-disubstituted 1,2,3-triazoles are inhibitors of RAC/CDC42 GTPases" was invented by Cornelis P. Vlaar (San Juan, Puerto Rico), Suranganie Dharmawardhane Flanagan (San Juan, Puerto Rico), Eliud Hernandez-O'farrill (San Juan, Puerto Rico) and Linette Castillo-Pichardo (San Juan, Puerto Rico).

According to the abstract* released by the U.S. Patent & Trademark Office: "Compounds are disclosed that inhibit RhoGTPases that are useful for inhibiting hyperprofilerative and neoplastic diseases. Specifically, the compounds inhibit the GTPases Rac and Cdc42 that are overactive or overexpressed in si...