US Patent Issued to University of Pittsburgh-Of the Commonwealth System of Higher Education on Sept. 15 for "Oncolytic viruses encoding recombinant transforming growth factor (TGF)-beta monomers and uses thereof" (Pennsylvania Inventors)

ALEXANDRIA, Va., Sept. 15 -- United States Patent no. 12,735,722, issued on Sept. 15, was assigned to University of Pittsburgh-Of the Commonwealth System of Higher Education (Pittsburgh).

"Oncolytic viruses encoding recombinant transforming growth factor (TGF)-beta monomers and uses thereof" was invented by Greg M. Delgoffe (Pittsburgh), Andrew P. Hinck (Pittsburgh) and Kristin DePeaux (Pittsburgh).

According to the abstract* released by the U.S. Patent & Trademark Office: "Oncolytic viruses encoding a recombinant form of TGF-Beta engineered to prevent homodimerization and recruitment of TGF-Beta receptor I are described. The engineered TGF-Beta monomers function as dominant-negative TGF-Beta inhibitors. Oncolytic viruses encoding a TGF-B...