US Patent Issued to UNIVERSITY OF MASSACHUSETTS on March 31 for "Methods for predicting ER-mediated DNA damage" (Massachusetts Inventors)

ALEXANDRIA, Va., March 31 -- United States Patent no. 12,590,950, issued on March 31, was assigned to UNIVERSITY OF MASSACHUSETTS (Boston).

"Methods for predicting ER-mediated DNA damage" was invented by D. Joseph Jerry (Boston), Prabin Kumar Dhangada Majhi (Boston), Aman Sharma (Boston) and Karen A. Dunphy (Boston).

According to the abstract* released by the U.S. Patent & Trademark Office: "Acute exposure to estrogenic chemicals is shown herein to induce DNA damage mediated by formation of ERAlpha-dependent R-loops. Disclosed herein are methods for evaluating the safety and activity of a xenoestrogen. Also disclosed are methods for identifying subject particularly susceptible to the genotoxic effects of endogenous estrogens or environmen...