ALEXANDRIA, Va., Aug. 26 -- United States Patent no. 12,398,378, issued on Aug. 26, was assigned to University of Massachusetts (Westborough, Mass.) and The Clinic for Special Children Inc. (Strasburg, Pa.).

"AAV-mediated gene therapy for maple syrup urine disease (MSUD)" was invented by Guangping Gao (Worcester, Mass.), Dan Wang (Worcester, Mass.), Jiaming Wang (Worcester, Mass.) and Kevin A. Strauss (Strasburg, Pa.).

According to the abstract* released by the U.S. Patent & Trademark Office: "In some aspects the disclosure provides compositions and methods for promoting expression of functional BCKDHA protein, which is the E1-alpha subunit of the branched-chain alpha-keto acid (BCAA) dehydrogenase complex, in a subject. In some aspects t...