ALEXANDRIA, Va., May 26 -- United States Patent no. 12,636,304, issued on May 26, was assigned to University of Iowa Research Foundation (Iowa City, Iowa).
"Metabolically stabilized double stranded mRNA" was invented by Kevin G. Rice (Iowa City, Iowa) and Samuel T. Crowley (Iowa City, Iowa).
According to the abstract* released by the U.S. Patent & Trademark Office: "Double stranded mRNA, e.g., produced in vitro, as well as method of making and using the ds mRNA, are provided. For example, the disclosure provides a method of expressing a prophylactic or therapeutic protein in mammalian cells in vivo, that includes introducing a composition comprising ds mRNA that encodes a protein to the mammalian cells in an amount effective to express th...