US Patent Issued to University of Florida Research Foundation on June 9 for "Use of metformin and analogs thereof to reduce RAN protein levels in the treatment of neurological disorders" (Florida Inventors)

ALEXANDRIA, Va., June 9 -- United States Patent no. 12,648,917, issued on June 9, was assigned to University of Florida Research Foundation Inc. (Gainesville, Fla.).

"Use of metformin and analogs thereof to reduce RAN protein levels in the treatment of neurological disorders" was invented by Laura Ranum (Gainesville, Fla.) and Tao Zu (Gainesville, Fla.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides the use of compounds of Formulae (I), (II), (III), (III-A), and (III-B) (e.g., metformin) in treating a neurological disease associated with repeat expansions and/or RAN protein accumulation, reducing the level of one or more repeat associated non-ATG (RAN) proteins, and reducing th...