US Patent Issued to University of Florida Research Foundation on June 23 for "Target validation and profiling of the RNA targets of small molecules" (Florida Inventor)

ALEXANDRIA, Va., July 15 -- United States Patent no. 12,661,409, issued on June 23, was assigned to University of Florida Research Foundation Inc. (Gainesville, Fla.).

"Target validation and profiling of the RNA targets of small molecules" was invented by Matthew D. Disney (Jupiter, Fla.).

According to the abstract* released by the U.S. Patent & Trademark Office: "A method for the precise cellular destruction of an oncogenic non-coding RNA with a RNA-binding small molecule conjugated with bleomycin A5 is described. The method affords reversal of phenotype. Bleomycin A5 was coupled to an RNA-binding molecule that selectively binds the microRNA-96 hairpin precursor (pri-miR-96). By coupling of bleomycin A5's free amine to the RNA-binding mo...