US Patent Issued to University of Florida Research Foundation on Jan. 20 for "Defining RNA-small molecule affinity landscapes enables design of a small molecule inhibitor of an oncogenic non-coding RNA" (Florida Inventors)

ALEXANDRIA, Va., Jan. 20 -- United States Patent no. 12,527,788, issued on Jan. 20, was assigned to University of Florida Research Foundation Inc. (Gainesville, Fla.).

"Defining RNA-small molecule affinity landscapes enables design of a small molecule inhibitor of an oncogenic non-coding RNA" was invented by Matthew D. Disney (Jupiter, Fla.) and Sai Pradeep Velagapudi (Jupiter, Fla.).

According to the abstract* released by the U.S. Patent & Trademark Office: "RNA drug targets are pervasive in cells but methods to design small molecules that target them are sparse. Herein, we report a general approach to score the affinity and selectivity of RNA motif-small molecule interactions identified via selection. Named High Throughput Structure-Act...