US Patent Issued to UNIVERSITY OF DUNDEE on Oct. 27 for "Ligase screening assay" (British, Taiwanese Inventors)

ALEXANDRIA, Va., Oct. 27 -- United States Patent no. 12,774,484, issued on Oct. 27, was assigned to UNIVERSITY OF DUNDEE (Dundee, Great Britain).

"Ligase screening assay" was invented by Satpal Virdee (Dundee, Great Britain) and Kuan-Chuan Pao (Douliu City, Taiwan).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to a method for identifying a MYCBP2 modulator. Suitable modulators are identified by modulation of MYCBP2 ubiquitin E3 ligase activity via covalent modification of either of two catalytic cysteines (C4520 and C4572) or by impeding the motion of a newly presented dynamic, so-called, mediator loop region where C4520 resides. The present invention also relates to the use of ...