US Patent Issued to University of Cincinnati on April 21 for "Materials and methods for immunosuppressive tumor microenvironment-targeted cancer therapy" (Ohio Inventors)

ALEXANDRIA, Va., April 21 -- United States Patent no. 12,605,395, issued on April 21, was assigned to University of Cincinnati (Cincinnati).

"Materials and methods for immunosuppressive tumor microenvironment-targeted cancer therapy" was invented by Xiaoyang Qi (Cincinnati) and Subrahmanya Duttu Vallabhapurapu (Cincinnati).

According to the abstract* released by the U.S. Patent & Trademark Office: "Many tumors induce and maintain an immunosuppressive tumor microenvironment (TME) that enables tumor to escape host immune system. The present disclosure identifies that cancer cells secrete exosome/microparticle-free, soluble, phosphorylated Hsp70 (pHsp70) (Heat Shock Protein 70 (Hsp70))), which triggers macrophage (M) M2 polarization. It is a...