US Patent Issued to University Health Network on Jan. 20 for "T cell receptors and methods of use thereof" (Canadian Inventors)

ALEXANDRIA, Va., Jan. 20 -- United States Patent no. 12,527,809, issued on Jan. 20, was assigned to University Health Network (Toronto).

"T cell receptors and methods of use thereof" was invented by Naoto Hirano (Toronto), Kenji Murata (Toronto) and Kayoko Saso (Toronto).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure is directed recombinant T cell receptors capable of binding an NY-ESO-1 epitope and nucleic acid molecules encoding the same. In some embodiments, the nucleic acid molecules further comprise a second nucleotide sequence, wherein the second nucleotide sequence or the polypeptide encoded by the second nucleotide sequence inhibits the expression of an endogenous TCR. Other asp...