ALEXANDRIA, Va., March 3 -- United States Patent no. 12,565,715, issued on March 3, was assigned to Twist Bioscience Corp. (South San Francisco, Calif.).
"Variant nucleic acid libraries for antibody optimization" was invented by Aaron Sato (Burlingame, Calif.).
According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are methods and compositions relating to libraries of optimized antibodies having nucleic acids encoding for an antibody comprising modified sequences. Libraries described herein include variegated libraries comprising nucleic acids each encoding for a predetermined variant of at least one predetermined reference nucleic acid sequence. Further described herein are protein libraries generated...