US Patent Issued to Trustees of Boston University on March 17 for "Methods and compositions relating to chimeric antigen receptors" (Massachusetts Inventors)

ALEXANDRIA, Va., March 17 -- United States Patent no. 12,577,288, issued on March 17, was assigned to Trustees of Boston University.

"Methods and compositions relating to chimeric antigen receptors" was invented by Wilson W. Wong (Brookline, Mass.) and Jang Hwan Cho (Chestnut Hill, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Described herein is a chimeric antigen receptor (CAR) platform with the ability to (a) serve as an ON/OFF switch (with the ability for tenability/titrability), (b) sense multiple antigens and perform logic computations, and/or (c) independently regulate multiple signaling pathways. The compositions provided herein permit the degree of control and discrimination necessary to opti...