US Patent Issued to TRUSTEES OF BOSTON COLLEGE on March 3 for "Enhanced platforms for unnatural amino acid incorporation in mammalian cells" (Massachusetts Inventors)

ALEXANDRIA, Va., March 3 -- United States Patent no. 12,565,646, issued on March 3, was assigned to TRUSTEES OF BOSTON COLLEGE (Chestnut Hill, Mass.).

"Enhanced platforms for unnatural amino acid incorporation in mammalian cells" was invented by Abhishek Chatterjee (Lexington, Mass.), Rachel E. Kelemen (Newton, Mass.) and Delilah Jewel (Chestnut Hill, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention involves the ability to 1) use a virus assisted directed evolution platform to significantly improve the activity of engineered nonsense-suppressor tRNAs in mammalian cells, 2) provide mutants of archaeal pyrrolysyl and E. coli leucyl tRNAs that show remarkably improved Uaa incorporation...