ALEXANDRIA, Va., Nov. 3 -- United States Patent no. 12,778,976, issued on Nov. 3, was assigned to Translate Bio Inc. (Lexington, Mass.).
"Subcutaneous delivery of messenger RNA" was invented by Shrirang Karve (Lexington, Mass.), Frank DeRosa (Lexington, Mass.), Zarna Bhavsar (Lexington, Mass.) and Michael Heartlein (Lexington, Mass.).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides, among other things, methods of formulating nucleic acid-containing nanoparticles with an enzyme to afford efficient delivery of payload to a cell or tissue of interest via subcutaneous administration. In some embodiments, the present invention provides a process in which mRNA-loaded lipid nanoparticles...