ALEXANDRIA, Va., June 16 -- United States Patent no. 12,655,095, issued on June 16, was assigned to TRANSLATE BIO INC. (Waltham, Mass.).
"TES-based cationic lipids" was invented by Shrirang Karve (Acton, Mass.) and Frank Derosa (Chelmsford, Mass.).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides, in part, TES-based lipid compounds of Formula (Ia), and sub-formulas thereof: or a pharmaceutically acceptable salt thereof. The compounds provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated w...