US Patent Issued to TOKYO INSTITUTE OF TECHNOLOGY, NOF on March 24 for "Branched type hetero monodispersed polyethylene glycol, production method thereof, and conjugate thereof" (Japanese Inventors)

ALEXANDRIA, Va., March 24 -- United States Patent no. 12,583,967, issued on March 24, was assigned to TOKYO INSTITUTE OF TECHNOLOGY (Tokyo) and NOF Corp. (Tokyo).

"Branched type hetero monodispersed polyethylene glycol, production method thereof, and conjugate thereof" was invented by Kazushi Kinbara (Tokyo), Tomoki Uruga (Tsukuba, Japan) and Tomoyuki Ohtake (Tsukuba, Japan).

According to the abstract* released by the U.S. Patent & Trademark Office: "A method of producing a compound represented by formula (3):includes: step (1) of performing coupling of a monodispersed polyethylene glycol derivative represented by formula (4) shown below with a compound represented by formula (5) shown below using a base catalyst having a pKa in an aqueou...