US Patent Issued to The Trustees of the University of Pennsylvania on Sept. 29 for "Modulation of expression of genes related to T cell exhaustion" (Pennsylvania, California Inventors)

ALEXANDRIA, Va., Sept. 30 -- United States Patent no. 12,747,431, issued on Sept. 29, was assigned to The Trustees of the University of Pennsylvania (Philadelphia).

"Modulation of expression of genes related to T cell exhaustion" was invented by E. John Wherry (Havertown, Pa.), Omar Khan (San Francisco) and Josephine Giles (Philadelphia).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides methods of preventing, reducing or reversing T cell exhaustion in a patient having a disease. The present invention also provides methods for treating a disease in a patient having the disease. The present invention also provides an engineered T cell, and uses thereof."

The patent was filed on May ...