US Patent Issued to The Trustees of the University of Pennsylvania on Sept. 29 for "Compositions useful in treatment of ornithine transcarbamylase (OTC) deficiency" (Pennsylvania Inventors)

ALEXANDRIA, Va., Sept. 30 -- United States Patent no. 12,747,429, issued on Sept. 29, was assigned to The Trustees of the University of Pennsylvania (Philadelphia).

"Compositions useful in treatment of ornithine transcarbamylase (OTC) deficiency" was invented by Lili Wang (Phoenixville, Pa.) and James M. Wilson (Philadelphia).

According to the abstract* released by the U.S. Patent & Trademark Office: "Viral vectors comprising engineered hOTC DNA and RNA sequences are provided which when delivered to a subject in need thereof are useful for treating hyperammonemia, ornithine transcarbamylase deficiency and symptoms associated therewith. Also provided are methods of using hOTC for treatment of liver fibrosis and/or cirrhosis in OTCD patient...