US Patent Issued to The Trustees of the University of Pennsylvania on Dec. 16 for "Non-signaling HIV fusion inhibitors and methods of use thereof" (Pennsylvania Inventors)

ALEXANDRIA, Va., Dec. 16 -- United States Patent no. 12,497,623, issued on Dec. 16, was assigned to The Trustees of the University of Pennsylvania (Philadelphia).

"Non-signaling HIV fusion inhibitors and methods of use thereof" was invented by James L Riley (Downingtown, Pa.), James A. Hoxie (Berwyn, Pa.), George J. Leslie (Philadelphia) and Max W. Richardson (Philadelphia).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to engineered cells expressing a fusion protein comprising a peptide fusion inhibitor and a CXCR4 protein that lacks signaling activity. Also provided are methods of suppressing, inhibiting, preventing or treating a HIV infection in a subject in need thereof using...