US Patent Issued to The Scripps Research Institute on Dec. 16 for "Incorporation of unnatural nucleotides and methods of use in vivo thereof" (California Inventors)

ALEXANDRIA, Va., Dec. 16 -- United States Patent no. 12,497,642, issued on Dec. 16, was assigned to The Scripps Research Institute (La Jolla, Calif.).

"Incorporation of unnatural nucleotides and methods of use in vivo thereof" was invented by Floyd E. Romesberg (La Jolla, Calif.), Yorke Zhang (La Jolla, Calif.), Aaron W. Feldman (La Jolla, Calif.) and Vivian T. Dien (La Jolla, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed herein are in vivo methods, compositions, and kits for producing nucleic acids which comprises at least one unnatural base. Disclosed herein are in vivo methods of producing a nucleic acid with an expanded genetic alphabet, the method comprising incorporating at least one ...