US Patent Issued to The Regents of the University of California on March 31 for "Bi-specific chimeric antigen receptor" (California Inventors)

ALEXANDRIA, Va., March 31 -- United States Patent no. 12,590,145, issued on March 31, was assigned to The Regents of the University of California (Oakland, Calif.).

"Bi-specific chimeric antigen receptor" was invented by Yvonne Yu-Hsuan Chen (Los Angeles) and Zenan Li Chang (Los Angeles).

According to the abstract* released by the U.S. Patent & Trademark Office: "Aspects of the disclosure relate to polypeptides comprising a signal peptide, an antigen-binding domain that specifically binds TGF-Beta, a peptide spacer, a transmembrane domain, and an endodomain. When expressed in a cell, the polypeptides are capable of not only neutralizing the TGF-Beta but also specifically triggering T-cell activation in the presence of TGF-Beta. T-cell act...