US Patent Issued to The Regents of the University of California, The J. David Gladstone Institutes, A Testamentary Trust Established Under the Will of J. David Gladstone on Oct. 6 for "Compositions and methods for modifying a target nucleic acid" (California Inventors)

ALEXANDRIA, Va., Oct. 6 -- United States Patent no. 12,753,412, issued on Oct. 6, was assigned to The Regents of the University of California (Oakland, Calif.) and The J. David Gladstone Institutes, A Testamentary Trust Established Under the Will of J. David Gladstone (San Francisco).

"Compositions and methods for modifying a target nucleic acid" was invented by Alexander Marson (San Francisco), Brian Shy (San Francisco), Justin Eyquem (San Francisco) and Vivasvan Vykunta (San Francisco).

According to the abstract* released by the U.S. Patent & Trademark Office: "The disclosure provides compositions and methods for for modifying an endogenous cell surface protein (e.g., an endogenous TCR) in a cell (e.g., a T cell) with a CAR or an exogen...