US Patent Issued to The Johns Hopkins University on June 23 for "BCG based vaccine compositions and methods of use thereof" (Maryland, Pennsylvania Inventors)

ALEXANDRIA, Va., July 15 -- United States Patent no. 12,661,393, issued on June 23, was assigned to The Johns Hopkins University (Baltimore).

"BCG based vaccine compositions and methods of use thereof" was invented by Alok Singh (Baltimore), Peter Um (Baltimore), Keira Cohen (Baltimore), William Bishai (Baltimore), Rulin Wang (Baltimore), Srinivasan Yegnasubramanian (Baltimore) and Trinity J. Bivalacqua (Philadelphia).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure relates to a BCG based therapeutic agent using a BCG strain that overexpresses the STING agonist, c-di-AMP. This BCG strain, called BCG-disA-OE, enhances the elevated trained immunity of macrophages and promotes early anti-vir...