US Patent Issued to The Johns Hopkins University on July 7 for "Small molecule RPN13 inhibitors with antitumor properties" (Maryland Inventors)

ALEXANDRIA, Va., July 7 -- United States Patent no. 12,673,918, issued on July 7, was assigned to The Johns Hopkins University (Baltimore).

"Small molecule RPN13 inhibitors with antitumor properties" was invented by Richard B.S. Roden (Baltimore) and Ravi K. Anchoori (Baltimore).

According to the abstract* released by the U.S. Patent & Trademark Office: "Compounds of formula (I), (II), and (III) having the structure shown below are presented: wherein R-R6 are defined herein. These molecules work as proteasome inhibitors and bind to the RPN13 subunit of the 19S regulatory particle, and can be used in methods of treating a condition or a disease, such as cancer, in a mammal."

The patent was filed on Dec. 4, 2020, under Application No. 17/7...